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KMID : 1035620170050060331
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Allergy Asthma & Respiratory Disease
2017 Volume.5 No. 6 p.331 ~ p.335
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Sensitization to component antigens in acute idiopathic urticaria in children
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Choi Young-Jin
Yoon Jung-Min
Jang Yeo-Sun
Oh Jae-Won
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Abstract
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Purpose: The aim of this study was to evaluate hidden allergens of acute idiopathic urticaria (AIU) in childhood by using the component-resolved diagnostics (CRD).
Methods: We applied CRD using pathogenesis-related protein family number 10 (PR-10) and nonspecific lipid transfer proteins (nsLTP).
Results: Twenty-two of the 74 AIU children (29.7%) were found to be positive on CRD. Ten children were positive to nMal d 1 for apple (value range, 1.10?40.59), 6 to rConr a 1 for hazelnut (1.53?11.97), 4 to rPru p 1 for peach (1.32?11.83). 6 to rAra h 8 for peanut (1.20?8.12), 6 to nAct d 8 for kiwi (0.85?3.32), 4 to rBet v 1 for birch (2.49?54.28), and 3 to rAln g 1 for alder (2.32?5.74). Six children were positive to nPru p 3 for peach (1.45?18.77), 4 to rCor a 8 for hazelnut (2.56?9.19), 2 to nArt v 3 for mugwort (3.40?7.42), and 3 to rBet v2 to profilin of birch (2.56?17.46). Ten children with AIU were positive to multiple component proteins. For hazelnut, 5 children were positive to PR-10 (rConr a 1) and nsLTP (rConr a 1). For peach, 3 children were positive to PR-10 (rPru p 1) and nsLTP (nPru p 3).
Conclusion: IgE sensitization to PR-10 or nsLTP may be allergen components for AIU in childhood.
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KEYWORD
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Urticaria, Allergen, Diagnosis
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